Selected Publications

• David Gems is currently completing a book on recent developments in the science of aging (2023).

• C.C. Kern, S. Townsend, A. Salzmann, N.B. Rendell, G.W. Taylor, R.M. Comisel, L.C. Foukas, J. Bähler, D. Gems. ‘C. elegans feed yolk to their young in a form of primitive lactation.’ Nature Communications (2021) 12: 5801. Recommended twice in Faculty Opinions as being of special significance in its field.

• Y. Zhao, H. Wang, R.J. Poole, D. Gems. ‘A common fln-2 mutation affects lethal pathology and lifespan in C. elegans.’ Nature Communications (2019) 10: 5087.

• M. Ezcurra, A. Benedetto, T. Sornda, A.F. Gilliat, C. Au, Q. Zhang, S. van Schelt, A.L. Petrache, H. Wang, Y. de la Guardia, S. Bar-Nun, E. Tyler, M.J. Wakelam, D. Gems. ‘C. elegans eats its own intestine to make yolk leading to multiple senescent pathologies.’ Current Biology (2018) 28: 2544-2556 (download pdf). See commentary, Science Aug 9th 2018. Recommended twice by F1000.

• Y. Zhao, A.F. Gilliat, M. Ziehm, M. Turmaine, H. Wang, M. Ezcurra, C. Yang, G. Phillips, D. McBay, W.B. Zhang, L. Partridge, Z. Pincus, D. Gems. ‘Two forms of death in ageing Caenorhabditis elegans.’ Nature Communications (2017) 8: 15458. (download pdf)

• C. Coburn, E. Allman, P. Mahanti, A. Benedetto, F. Cabreiro, Z. Pincus, F. Matthijssens, C. Araiz, A. Mandel, M. Vlachos, S.-A. Edwards, G. Fischer, A. Davidson, R.E. Pryor, A. Stevens, F.J. Slack, N. Tavernarakis, B. Braeckman, F.C. Schroeder, K. Nehkre, D. Gems. 'Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans.' PLoS Biology (2013) 11: e1001613. (download pdf)

• F. Cabreiro, C. Au, K.-Y. Leung, N. Vergara-Irigaray, H.M. Cocheme, T. Noori, D. Weinkove, E. Schuster, N.D.E. Greene, D. Gems. 'Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.' Cell (2013) 153: 228-239. (download pdf)

• C. Burnett, S. Valentini, F. Cabreiro, M. Goss, M. Somogyvari, M.D. Piper, M. Hoddinott, G. L. Sutphin, V. Leko, J.J. McElwee, R.P. Vazquez-Manrique, A.-M. Orfila, D. Ackerman, C. Au, G. Vinti, M. Riesen, K. Howard, C. Neri, A. Bedalov, M. Kaeberlein, C. Soti, L. Partridge, D. Gems. 'Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila.' Nature (2011) 477: 482-485. (download pdf)

• C. Selman, J.M.A. Tullet, D. Wieser, E. Irvine, S.J. Lingard, A.I. Choudhury, M. Claret, H. Al-Qassab, D. Carmignac, F. Ramadani, A. Woods, I.C.A. Robinson, E. Schuster, R.L. Batterham, S.C. Kozma, G. Thomas, D. Carling, K. Okkenhaug, J.M. Thornton, L. Partridge, D. Gems, D.J. Withers. 'Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan.' Science (2009) 326: 140-144. (download pdf file)

• R. Doonan, J.J. McElwee, F. Matthijssens, G.A. Walker, K. Houthoofd, P. Back, A. Matscheski, J.R. Vanfleteren, D. Gems. 'Against the oxidative damage theory of aging: Superoxide dismutases protect against oxidative stress but have little or no effect on lifespan in C. elegans.' Genes and Development (2008) 22: 3236-3241. (download pdf) (download supplement)

• D. Clancy, D. Gems, S.J. Leevers, S. Oldham, H. Stocker, E. Hafen, L. Harshman and L. Partridge. 'Extension of life span by loss of CHICO, a Drosophila insulin receptor substrate protein.' Science (2001) 292, 104-106. (download pdf file)

• D. Gems and D.L. Riddle. 'Longevity in Caenorhabditis elegans reduced by mating but not gamete production.' Nature (1996) 379, 723-725. (download pdf file)